I'm running a 15x8 6UL and a 225/45 with almost no problems. I'm still running fender liners and I've only had to bend in the liner mounting tabs on the front. At the rear, I had a tire snag the inner fender lip at the track, but I was able to pry it back in with a cheater bar - no fuss, no muss.
However, if you haven't already found out, the selection of 225/45 tires has dwindled down to about 1 street tire - the Hankook RS3. From what I understand, it's a great tire, but with its 140 treadwear rating, I'm not sure how long it would last as a DD tire. So, as my old RS2s wear out, I'm debating on whether I should pop for a set of RS3s or downsize to a 205/50 Dunlop Star Spec.